GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs12131428 | 1 | rs6669434 | chr1:162413093 | HSD17B7 | chr1:162760496-162782607:+ | 0.39 | 4.12 | 4.42E-5 | Discordance in emotional problems in monozygotic twins |
| THCA | cis | rs2275426 | 1 | rs6669522 | chr1:46397941 | CCDC163P | chr1:45960581-45965646:- | -0.52 | -10.14 | 4.96E-22 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6669522 | chr1:46397941 | GPBP1L1 | chr1:46092978-46152302:- | 0.15 | 3.83 | 0.000147 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6669522 | chr1:46397941 | MMACHC | chr1:45965856-45976737:+ | -0.21 | -4.56 | 6.37E-6 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6669522 | chr1:46397941 | MUTYH | chr1:45794915-45806142:- | 0.3 | 8.15 | 3.33E-15 | Body mass index |
| THCA | cis | rs7552404 | 1 | rs6672180 | chr1:76123973 | MSH4 | chr1:76262630-76378923:+ | 0.25 | 4.26 | 2.42E-5 | Blood metabolite levels;Acylcarnitine levels |
| THCA | cis | rs2275426 | 1 | rs6672898 | chr1:46290588 | CCDC163P | chr1:45960581-45965646:- | -0.51 | -10.03 | 1.24E-21 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6672898 | chr1:46290588 | GPBP1L1 | chr1:46092978-46152302:- | 0.16 | 4.07 | 5.54E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6672898 | chr1:46290588 | MMACHC | chr1:45965856-45976737:+ | -0.19 | -4.28 | 2.28E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6672898 | chr1:46290588 | MUTYH | chr1:45794915-45806142:- | 0.31 | 8.34 | 7.97E-16 | Body mass index |
| THCA | cis | rs9782955 | 1 | rs6673218 | chr1:236041062 | LYST | chr1:235824345-236046940:- | -0.32 | -9.66 | 2.81E-20 | Systemic lupus erythematosus |
| THCA | cis | rs9782955 | 1 | rs6673237 | chr1:236041129 | LYST | chr1:235824345-236046940:- | 0.31 | 9.71 | 1.91E-20 | Systemic lupus erythematosus |
| THCA | cis | rs12134133 | 1 | rs6673333 | chr1:207459147 | CD55 | chr1:207494817-207534309:+ | 0.2 | 7.71 | 7.34E-14 | Posterior cortical atrophy and Alzheimer's disease |
| THCA | cis | rs12304921 | 1 | rs66744607 | chr12:51336491 | SLC11A2 | chr12:51373319-51422058:- | -0.23 | -4.7 | 3.34E-6 | Type 2 diabetes |
| THCA | cis | rs12304921 | 1 | rs66744607 | chr12:51336491 | TFCP2 | chr12:51488608-51566917:- | -0.19 | -4.01 | 6.94E-5 | Type 2 diabetes |